Soluble vascular cell adhesion molecular-1 is a potential biological indicator of hemophilic arthropathy
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چکیده
منابع مشابه
Soluble vascular cell adhesion molecular-1 is a potential biological indicator of hemophilic arthropathy
Hemophilic arthropathy is the most common chronic complication in patients with hemophilia. The pathogenesis of hemophilic arthropathy involves the inflammatory processes associated with rheumatoid arthritis (RA). Determining the severity and/or progression of joint damage is crucial when evaluating the effect of treatment modalities. Identifying reliable biomarkers in the peripheral blood of p...
متن کاملHemophilic Arthropathy.
The musculoskeletal manifestations of hemophilia A and B are some of the most common presenting symptoms and continue to be challenging to practitioners. Hemophilic arthropathy, if not initially adequately treated and managed, may lead to debilitating disease and eventually require the consideration of major surgery, including total joint arthroplasty. Thorough comprehension of the pathophysiol...
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Spontaneous joint bleeding and repeated hemarthroses lead to hemophilic arthropathy-a debilitating disease with a significant negative impact on mobility and quality of life. Iron, cytokines, and angiogenic growth factors play a pivotal role in the onset of the inflammatory process that involves the synovial tissue, articular cartilage, and subchondral bone, with early damages and molecular cha...
متن کاملUnraveling hemophilic arthropathy.
In this issue of Blood, Acharya and colleagues provide evidence for the role of angiogenesis in the pathophysiology of hemophilic joint disease. Is this the linchpin that unravels this important clinical condition or merely a cog in a not so stepwise process?
متن کاملOsteoporosis/osteopenia and hemophilic arthropathy in severe hemophilic patients.
BACKGROUND Types A and B hemophilia are coagulation disorders associated with many complications. Osteoporosis is a skeletal condition characterized by the decreased density of normally mineralized bone. This study aims to determine the relationship between osteoporosis and hemophilic arthropathy in severe hemophilia patients over the age of 20 years in Kerman, Iran. METHODS We performed a cr...
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ژورنال
عنوان ژورنال: Medicine
سال: 2016
ISSN: 0025-7974
DOI: 10.1097/md.0000000000005384